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The stress of interacting
with others causes tumours to shrink, and even go into
remission, according to a study published in the journal
Cell.
The study suggests that people with cancer could see an
improvement if they change their lifestyle to include
more company, rather than less.
Stress is widely considered to be damaging to h ealth,
although the latest findings suggest that manageable
levels of stress could help the immune system fight
disease.
The findings conflict with many recent studies which
have linked high stress levels to a higher
susceptibility to cancer and lower survival rates.
The mice-based study was led by Matthew During of the
Ohio State University, who said it had implications for
the optimal lifestyle for cancer patients.
Traditional clinical treatments like chemotherapy,
radiation treatment and surgery should be complemented
with attention to the living conditions of cancer
patients, During said.
The goal was to live a life that was physically and
socially richer, and more challenging, not to minimise
stress in an attempt to combat the disease, he said.
During said lifestyle issues and brain reactions had
been regarded traditionally by clinicians as a ‘soft
area’ of cancer care programmes.
Instead, During's paper suggests focusing more on
people's perceptions of disease, their social
interactions and environment, in the treatment of
cancer.
Mice with cancer that were moved from their standard
laboratory living quarters which were shared by groups
of five animals to larger cages with up to 20 other mice
saw a huge boost to their condition.
Tumours in these mice saw their tumours shrink by an
average of 77% (43% by volume), and 5% had no signs of
cancer at all after three weeks under the new
conditions, which included more space to play in and
more toys.
However, the stress of social interaction was
highlighted as the main factor prompting the beneficial
effects on cancer.
The changes are linked to a stress-linked protein called
brain-derived neurotrophic factor (BDNF). It inhibits
the growth of tumours by shutting down the production of
the hormone, leptin.
Researchers concluded that there was no reason why the
findings should not apply to humans as well, and could
pave the way for new drugs based on the same protein and
hormones.
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